- Betye Saar (born 1926)
- Gaetano Sabatini (1703–1734), Italian draftsman and painter
- Jacques Sablet (1749–1803)
- Pieter Jansz Saenredam (1597–1665)
- Cornelis Saftleven (1607–1681)
- Herman Saftleven (1609–1685)
- Kay Sage (1898–1963)
- Anne Said (1914-1995)
- Jean-Pierre Saint-Ours (1752–1809)
- Saitō Kiyoshi (1907–1997)
- Sakai Hōitsu (1761–1828)
- Adam Saks (born 1974)
- Tahir Salahov (born 1928)
- Stanislaw Samostrzelnik (1480–1541)
- Hugo Sánchez B. (born 1940)
- Joop Sanders (born 1921)
- Hans Sandreuter (1850–1901)
- Bernat Sanjuan (1915–1979)
- John Singer Sargent (1856–1925)
- Andrea del Sarto (1487–1531)
- Arthur Sarkissian (born 1960), Armenian painter
- Martiros Saryan (1880–1972), Armenian painter
- Wilhelm Sasnal (born 1972)
- Satake Yoshiatsu (1748–1785)
- Satō Junpei (born 1956), Western-style painter in Japan
- Raymond Saunders (born 1934)
- Antonio Saura (1930–1998)
- Anne Savage (1896–1971)
- Roelant Savery (1576–1639)
- Jenny Saville (born 1970)
- Konstantin Savitsky (1844–1905)
- Alexei Kondratyevich Savrasov (1830–1897)
- Sawa Sekkyō
- Jan Sawka (born 1946)
- Fikret Muallâ Saygı (1903–1967), Turkish painter
- Godfried Schalcken (1643–1706)
- Louis Schanker (1903–1981)
- Egon Schiele (1890–1918)
- Jakub Schikaneder (1855–1924)
- Helene Schjerfbeck (1862–1946)
- Rudolf Schlichter (1890–1955)
- Richard Schmid (born 1934)
- George Schmidt (born 1944)
- Hans Werner Schmidt (1859–1950)
- Karl Schmidt-Rottluff (1884–1976)
- Randall Schmit (born 1955)
- Stella Schmolle (1908–1975), British painter
- Julian Schnabel (born 1952)
- Gérard Ernest Schneider (1896–1986)
- Georg Scholz (1890–1945)
- Floris van Schooten (1590–1655)
- Otto Marseus van Schrieck (1619–1678)
- Georg Schrimpf (1889–1938)
- Adolf Schrödter (1805–1875)
- Daniel Schultz (1615–1683)
- Ethel Schwabacher (1903–1984)
- Carlos Schwabe (1877–1926)
- Randolph Schwabe (1885–1948), English painter and etcher
- Hans Schwarz (1922–2003), Austrian portrait painter
- Kurt Schwitters (1887–1948)
- Alexander Scott (1872–1932), British
- Richard T. Scott (born 1980), American
- Samuel Scott (1703–1772) English marine/topographical painter and etcher
- Tom Scott RSA (1854–1927)
- William Edouard Scott (1884–1964)
- Eduardo Lefebvre Scovell (1864–1918)
- Sean Scully (born 1945)
- Felipe Seade (1912–1969)
- Otakar Sedloň (1885–1973)
- Richard Sedlon (1900–1991)
- Lasar Segall (1891–1957)
- Daniel Seghers (1590–1661)
- Gerard Seghers (1591–1651)
- Hercules Seghers (1589–1638)
- Kurt Seligmann (1900–1962)
- Jacek Sempoliński (born 1927)
- Sengai (1750–1837)
- Sohrab Sepehri (1928–1980)
- Zinaida Serebriakova (1884–1967)
- Valentin Aleksandrovich Serov (1865–1911)
- Clément Serveau (1886–1972)
- Bela Čikoš Sesija (1864–1931)
- Sesshū Tōyō (1420–1506)
- Georges Seurat (1859–1891)
- Gino Severini (1883–1966)
- Joseph Severn (1793–1879)
- Shang Xi (fl. c. 1430–1440)
- Emily Shanks (1857–1936)
- Shao Mi (1592–1642)
- Harold Shapinsky (1925–2004)
- SharakuTōshūsai
- Sylvester Shchedrin (1791–1830)
- Millard Sheets (1907–1989)
- Samuel Shelley (1750–1808), English miniaturist
- Rupert Shephard (1909–1992), English painter and illustrator
- Donald Sherwood (born 1930), graphic artist, Minnesota boundary waters landscape artist
- Shen Che-Tsai (1926–2017)
- Shen Quan (1682–1760)
- Shen Shichong
- Shen Zhou (1427–1509)
- Sheng Mao
- Sheng Maoye
- Shi Rui
- Shi Zhonggui (born 1954)
- Shiba Kōkan (1747–1818)
- Shibata Zeshin (1807–1891)
- Shigemasa Kitao (1739–1820)
- Shimamoto Shōzo (born 1928)
- Shimomura Kanzan (1873–1930)
- Siona Shimshi (born 1939)
- Shin Saimdang (1504–1551)
- Shin Wui (1769–1847)
- Shin Yun-bok (born 1758)
- Shingei Geiami (1431–1485)
- Shinoda Toko (born 1913)
- Ivan Shishkin (1832–1898)
- Shitao (1642–1707)
- Harry Shoulberg (1903–1995)
- Shūbun Tenshō (?–1450)
- Shukei Sesson (1504–1589)
- Daryush Shokof (born 1954)
- Kevin A Short (born 1960)
- Ram Chandra Shukla (born 1925)
- Shunbaisai Hokuei
- Shunkōsai Hokushū
- Walter Sickert (1860–1942)
- Gregorius Sickinger (1558–1631)
- Henryk Siemiradzki (1843–1902)
- Paul Signac (1863–1935)
- Telemaco Signorini (1835–1901)
- Sim Sa-jeong (1707–1769)
- Ramón Silva (1890–1919)
- Josef Sima (1891–1971)
- Hugo Simberg (1873–1917)
- Jozef Simmler (1823–1868)
- Sidney Simon (1917–1997)
- Edward Simmons (1852–1931)
- Enrique Simonet (1866–1927)
- David Simpson (born 1928)
- Ruth Simpson (1889–1964), English painter
- David Alfaro Siqueiros (1896–1974)
- Mario Sironi (1885–1961)
- Alfred Sisley (1839–1899)
- Michael Sittow (1469–1525)
- P.C. Skovgaard (1817–1875)
- Antonín Slavíček (1870–1910)
- Fyodor Slavyansky (1817–1876)
- Sylvia Sleigh (1916–2010)
- Max Slevogt (1868–1932)
- Władysław Ślewiński (1854–1918)
- Pieter Cornelisz van Slingelandt (1640–1691)
- Hamilton Sloan (born 1946)
- Leon Polk Smith (1906–1996)
- Matthew Smith (1879–1959)
- William Twigg-Smith (1883–1950)
- Xanthus Russell Smith (1839–1929)
- Franciszek Smuglewicz (1745–1807)
- Eero Snellman (1890–1951)
- Peter Snow (1927–2008)
- Sylvia Snowden (born 1942)
- Joan Snyder (born 1940)
- Sō Shiseki (1715–1786)
- Sōami (?–1525)
- Gerard Soest (1600–1681)
- Xul Solar (1887–1963)
- Koloman Sokol (1902–2003)
- Anton Solomoukha (born 1945)
- Konstantin Somov (1869–1939)
- Jens Søndergaard (1895–1957)
- Song Maojin
- Song Xu (1525–?)
- Rajesh Soni (born 1981)
- David G. Sorensen (1937–2011)
- Hendrik Martenszoon Sorgh (1610–1670)
- Joaquín Sorolla y Bastida (1863–1923)
- John Souch (c1593–1645)
- Pierre Soulages (born 1919)
- Camille Souter (born 1929)
- Chaim Soutine (1894–1944)
- Isaac Soyer (1902–1981)
- Moses Soyer (1899–1974)
- Raphael Soyer (1899–1987)
- Austin Osman Spare (1886–1956)
- Sir Stanley Spencer (1891–1959)
- Nancy Spero (1926–2009)
- Carl Spitzweg (1808–1885)
- Sebastian Spreng (born 1956)
- Nicolas de Staël (1914–1955)
- Jan Stanisławski (1860–1907)
- Otto Stark (1859–1926)
- Wojciech Korneli Stattler (1800–1875)
- Christian W. Staudinger (born 1952)
- Karl Stauffer-Bern (1857–1891)
- Henryk Stażewski (1894–1988)
- Karel Štěch (1908–1982)
- T. C. Steele (1847–1926)
- Jan Steen (1626–1679)
- Hendrik van Steenwijk I (1550–1603)
- Hendrik van Steenwijk II (1580–1649)
- Philip Wilson Steer (1860–1942)
- Joe Stefanelli (born 1921)
- Johann Gottfried Steffan (1815–1905)
- Georges Stein (1818–1890)
- Jacob Steinhardt (1887–1968)
- Eduard von Steinle (1810–1886)
- Théophile Steinlen (1859–1923)
- Juan Carlos Stekelman (born 1936)
- Frank Stella (born 1936)
- Joseph Stella (1877–1946)
- Hedda Sterne (1910–2011)
- Matej Sternen (1870–1949)
- Helen Stevenson (fl.1920–1935)
- Andrew Stevovich (born 1948)
- Julius LeBlanc Stewart (1855–1919)
- LeConte Stewart (1891–1990)
- Clyfford Still (1904–1980)
- Tobias Stimmer (1539–1584)
- Andries Stock, Dutch Baroque painter (1580–1648)
- Stan Stokes
- Matthias Stom (1600–1652)
- Abraham Storck (1644–1708)
- William Stott (1857–1900)
- Hendrick van Streeck (1659–after 1720)
- Juriaen van Streeck (1632–1687)
- Sudip Roy (born 1960)
- Arthur Streeton (1867–1943)
- Bartlomiej Strobel (1591–1650)
- Joseph Dwight Strong (1853–1899)
- Bernardo Strozzi (1581–1644)
- Drew Struzan (born 1947)
- Zofia Stryjenska (1891–1976)
- Wladyslaw Strzeminski (1893–1952)
- Gilbert Stuart (1755–1828)
- George Stubbs (1724–1806)
- Franz Stuck (1863–1928)
- Walter Stuempfig (1914–1970)
- January Suchodolski (1797–1875)
- Serge Sudeikin (1882–1946)
- Alberto Sughi (born 1928)
- Sugimura Jihei
- Sugiyama Yasushi (1909–1993)
- William Holmes Sullivan (1836–1908)
- Altoon Sultan (born 1948)
- Sava Šumanović (1896–1942)
- Kelly Sueda (born 1972)
- Sun Junze
- Sun Kehong (1533–1611)
- Sun Long
- Victor Surbek (1885–1975)
- Vasily Surikov (1848–1916)
- George B. Sutherland
- Graham Sutherland (1903–1980)
- Carol Sutton (born 1945)
- Linda Sutton (born 1947)
- Marc-Aurèle de Foy Suzor-Coté (1869–1937)
- Suzuki Harunobu (1724–1770)
- Max Švabinský (1873–1962)
- Max Walter Svanberg (1912–1994)
- Eva Švankmajerová (1940–2005)
- Svend Rasmussen Svendsen (1864–1945)
- Sardar Sobha Singh
- Sergei Sviatchenko (born 1952)
- Herman van Swanevelt (1604–1655)
- Roger Swainston (born 1960)
- Sigurd Swane (1879–1973)
- Albert Swinden (1901–1961)
- Fedot Sychkov (1870–1958)
- George Gardner Symons (1861–1930)
- Józef Szermentowski (1833–1876)
- Pál Szinyei Merse (1845–1920)
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