- Alejandro Obregón (1920–1992), Colombian painter, muralist, sculptor and engraver
- Bencho Obreshkov (1899–1970), Bulgarian painter
- Jacques-François Ochard (1800–1870), French artist and teacher
- Jacob Ochtervelt (1634–1682)
- Leonard Ochtman (1854–1935), American Impressionist painter
- Ogata Gekkō (1859–1920)
- Ogata Kenzan (1663–1743)
- Ogata Kōrin (1658–1716)
- Juan O'Gorman (1905–1982), Mexican painter and architect
- Ogura Yuki (1895–2000)
- Dorothea Warren O'Hara (1873–1972), American ceramic artist
- Ohara Koson (1877–1945)
- Doug Ohlson (1936–2010)
- Michalis Oikonomou (1888–1933)
- Okada Beisanjin (1744–1820)
- Okada Hanko (1782–1846)
- Okamoto Tarō (1911–1996)
- Georgia O'Keeffe (1887–1986), American artist
- Aloysius O'Kelly (1853–1941)
- Okuda Gensō (1912–2003)
- Okumura Masanobu (1686–1764)
- Okumura Togyu (1889–1990)
- Jules Olitski (1922–2007), American abstract painter, printmaker, and sculptor
- Viktor Oliva (1861–1928), Czech painter and illustrator
- Nathan Oliveira (1928–2010), American painter, printmaker, and sculptor
- Olivia Peguero (born 1963), Dominican American painter and sculptor
- Ceferí Olivé (1907–1995), Catalan watercolor painter
- Madge Oliver (1875–1924), British painter
- Francisco Oller (1833–1917)
- Frank O'Meara (1853–1888)
- Onchi Koshiro (1891–1955)
- Julian Onderdonk (1882–1922)
- Ono Tadashige (1909–1990)
- Maria van Oosterwijk (1630–1693), Dutch Baroque painter, specializing in still-lifes
- Bruce Onobrakpeya (born 1932), printmaker, painter and sculptor
- John Opie (1761–1807), Cornish historical and portrait painter
- Andrea Orcagna (1320–1368), Italian painter, sculptor, and architect
- William Quiller Orchardson (1835–1910), Scottish portraitist and painter of domestic and historical subjects
- Edward Otho Cresap Ord, II (1858–1923), American painter & poet
- Bryan Organ (born 1935), English painter
- Emil Orlik (1870–1932), Austrian painter, etcher, and lithographer
- Aleksander Orłowski (1777–1832), Polish painter, sketch maker, and pioneer of lithography
- José Clemente Orozco (1883–1949), Mexican social realist painter
- Sir William Orpen (1878–1931), Irish portrait painter
- Manuel Ortiz de Zarate (1887–1946), Chilean painter
- George Earl Ortman (1926–2015)
- Erik Ortvad (1917–2008), Danish painter, founding member of the COBRA avant-garde movement
- Walter Osborne (1859–1903)
- Adriaen van Ostade (1610–1685), Dutch genre painter
- Isaac van Ostade (1621–1649)
- Ilya Ostroukhov (1858–1929)
- Ota Masamitsu (1892–1975)
- Otake Chikuha (1878-1936)
- Johann Friedrich Overbeck (1789–1869), German painter and member of the Nazarene movement
- Auseklis Ozols (born 1941), American painter and teacher
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